abstract：:Tetracenomycin X (Tcm X) has been reported to have antitumour activity in various cancers, but there have not been any studies on its activity with respect to lung cancer to date. Therefore, this study aims to investigate the anti-lung cancer activity of Tcm X. In this study, we found that tetracenomycin X showed anti...

journal_title：Marine drugs

authors： Qiao X,Gan M,Wang C,Liu B,Shang Y,Li Y,Chen S

更新日期：2019-01-18 00:00:00

abstract：:The crustacean processing industry produces large quantities of waste by-products (up to 70%). Such wastes could be used as raw materials for producing chitosan, a polysaccharide with a unique set of biochemical properties. However, the preparation methods and the long-term stability of chitosan-based products limit t...

journal_title：Marine drugs

authors： Bardakova KN,Akopova TA,Kurkov AV,Goncharuk GP,Butnaru DV,Burdukovskii VF,Antoshin AA,Farion IA,Zharikova TM,Shekhter AB,Yusupov VI,Timashev PS,Rochev YA

更新日期：2019-01-10 00:00:00

abstract：:Two previously unreported citrinin dimer derivatives, penicitol D (1) and 1-epi-citrinin H1 (2), were isolated from the culture of a deep sea-derived fungus Penicillium citrinum NLG-S01-P1, together with 11 biogenetic related compounds (3⁻13). A plausible biogenetic pathway for compounds 2⁻4 was proposed. Their struct...

journal_title：Marine drugs

authors： Wang W,Liao Y,Zhang B,Gao M,Ke W,Li F,Shao Z

更新日期：2019-01-10 00:00:00

abstract：:The small-spotted catshark is one of the most abundant elasmobranchs in the Northeastern Atlantic Ocean. Although its landings are devoted for human consumption, in general this species has low commercial value with high discard rates, reaching 100% in some European fisheries. The reduction of post-harvest losses (dis...

journal_title：Marine drugs

authors： Blanco M,Vázquez JA,Pérez-Martín RI,G Sotelo C

更新日期：2019-01-09 00:00:00

abstract：:Nanofibrous structures mimicking the native extracellular matrix have attracted considerable attention for biomedical applications. The present study aims to design and produce drug-eluting core-shell fibrous scaffolds for wound healing and skin tissue engineering. Aloe vera extracts were encapsulated inside polymer f...

journal_title：Marine drugs

authors： Zahedi E,Esmaeili A,Eslahi N,Shokrgozar MA,Simchi A

更新日期：2019-01-05 00:00:00

abstract：:In this study, sulfated polysaccharide-rich extracts were isolated from 22 tropical seaweeds (4 red, 11 brown, and 7 green) found in northeastern Brazil, and evaluated for the role of anticoagulant agents. Fifteen of the extracts showed anticoagulant activity, including all the extracts from green seaweeds. Udoteaflab...

journal_title：Marine drugs

authors： Mendes Marques ML,Presa FB,Viana RLS,Costa MSSP,Amorim MOR,Bellan DL,Alves MGCF,Costa LS,Trindade ES,Rocha HAO

更新日期：2018-12-21 00:00:00

abstract：:A general protocol for the asymmetric synthesis of 3-N-arylmethylated right-half model compounds of renieramycins was developed, which enabled structure⁻activity relationship (SAR) study of several 3-N-arylmethyl derivatives. The most active compound (6a) showed significant cytotoxic activity against human prostate ca...

journal_title：Marine drugs

authors： Matsubara T,Yokoya M,Sirimangkalakitti N,Saito N

更新日期：2018-12-20 00:00:00

abstract：:Certain strains of cyanobacteria produce a wide array of cyanotoxins, such as microcystins, lyngbyatoxins and aplysiatoxins, that are associated with public health issues. In this pilot study, an approach combining LC-MS/MS and molecular networking was employed as a rapid analytical method to detect aplysiatoxins pres...

journal_title：Marine drugs

authors： Ding CYG,Pang LM,Liang ZX,Goh KKK,Glukhov E,Gerwick WH,Tan LT

更新日期：2018-12-13 00:00:00

abstract：:Ten new triterpenoid compounds with structure diversity of the C-17 side-chain, including nine tirucallanes, named xylocarpols A⁻E (1⁻5) and agallochols A⁻D (6⁻9), and an apotirucallane, named 25-dehydroxy protoxylogranatin B (10), were isolated from the mangrove plants Xylocarpus granatum, Xylocarpus moluccensis, and...

journal_title：Marine drugs

authors： Jiang ZP,Luan ZL,Liu RX,Zhang Q,Ma XC,Shen L,Wu J

更新日期：2018-12-06 00:00:00

abstract：:The marine nemertean Cephalothrix simula originates from the Pacific Ocean but in recent years has been discovered in northern Europe. The species has been associated with high levels of the marine neurotoxin Tetrodotoxin, traditionally associated with Pufferfish Poisoning. This study reports the first discovery of tw...

journal_title：Marine drugs

authors： Turner AD,Fenwick D,Powell A,Dhanji-Rapkova M,Ford C,Hatfield RG,Santos A,Martinez-Urtaza J,Bean TP,Baker-Austin C,Stebbing P

更新日期：2018-11-16 00:00:00

abstract：:Cyclic imine toxins are neurotoxic, macrocyclic compounds produced by marine dinoflagellates. Mass spectrometric screenings of extracts from natural plankton assemblages revealed a high chemical diversity among this toxin class, yet only few toxins are structurally known. Here we report the structural characterization...

journal_title：Marine drugs

authors： Zurhelle C,Nieva J,Tillmann U,Harder T,Krock B,Tebben J

更新日期：2018-11-14 00:00:00

abstract：:Ecklonia cava (E. cava) can alleviate vascular dysfunction in diseases associated with poor circulation. E. cava contains various polyphenols with different functions, but few studies have compared the effects of these polyphenols. Here, we comparatively investigated four major compounds present in an ethanoic extract...

journal_title：Marine drugs

authors： Oh S,Son M,Lee HS,Kim HS,Jeon YJ,Byun K

更新日期：2018-11-09 00:00:00

abstract：:The striking rise of methicillin-resistant Staphylococcus aureus (MRSA) infections has become a serious threat to public health worldwide. In an effort to search for new anti-MRSA agents from natural products, a bioassay-guided phytochemical study was conducted on the semi-mangrove plant Myoporum bontioides A. Gray, w...

journal_title：Marine drugs

authors： Dong LM,Huang LL,Dai H,Xu QL,Ouyang JK,Jia XC,Gu WX,Tan JW

更新日期：2018-11-08 00:00:00

abstract：:The methods to obtain chitooligosaccharides are tightly related to the physicochemical properties of the end products. Knowledge of these physicochemical characteristics is crucial to describing the biological functions of chitooligosaccharides. Chitooligosaccharides were prepared either in a single-step enzymatic hyd...

journal_title：Marine drugs

authors： Sánchez Á,Mengíbar M,Fernández M,Alemany S,Heras A,Acosta N

更新日期：2018-11-02 00:00:00

abstract：:Carotenoids are natural pigments that contribute to light harvesting and photo-protection in photosynthetic organisms. In this study, we analyzed the carotenoid profiles, including mono-hydroxy and epoxy-carotenoids, in the economically valuable red seaweed Pyropia yezoensis, to clarify the detailed biosynthetic and m...

journal_title：Marine drugs

authors： Koizumi J,Takatani N,Kobayashi N,Mikami K,Miyashita K,Yamano Y,Wada A,Maoka T,Hosokawa M

更新日期：2018-11-01 00:00:00

abstract：:Chemical investigation of the methanol extract of the Vietnamese marine sponge Ircinia echinata led to the isolation of six new 9α-hydroxy-5α,6α-epoxysterols: 5α,6α-epoxycholesta-7,22(E)-dien-3β,9α-diol (1), 5α,6α-epoxycholesta-7,24(28)-dien-3β,9α-diol (2), (24R)-5α,6α-epoxy-24-ethyl-cholesta-7-en-3β,9α-diol (3), 5α,6...

journal_title：Marine drugs

authors： Trinh TTV,Truong BN,Longeon A,Doan TMH,Deville A,Chau VM,Pham VC,Bourguet-Kondracki ML

更新日期：2018-11-01 00:00:00

abstract：:Spumigins are marine natural products derived from cyanobacteria Nodulariaspumigena, which mimics the structure of the d-Phe-Pro-Arg sequence and is crucial for binding to the active site of serine proteases thrombin and factor Xa. Biological evaluation of spumigins showed that spumigins with a (2S,4S)-4-methylproline...

journal_title：Marine drugs

authors： Žula A,Będziak I,Kikelj D,Ilaš J

更新日期：2018-10-27 00:00:00

abstract：:The benefit of carotenoids to human health is undeniable and consequently, their use for this purpose is growing rapidly. Additionally, the nutraceutical properties of carotenoids have attracted attention of the food industry, especially in a new market area, the 'cosmeceuticals.' Marine organisms (microalgae, seaweed...

journal_title：Marine drugs

authors： Viera I,Pérez-Gálvez A,Roca M

更新日期：2018-10-22 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a PI3K-related serine/threonine protein kinase that functions as a master regulator of cellular growth and metabolism, in response to nutrient and hormonal stimuli. mTOR functions in two distinct complexes-mTORC1 is sensitive to rapamycin, while, mTORC2 is insensitive to this dr...

journal_title：Marine drugs

authors： Ruiz-Torres V,Losada-Echeberría M,Herranz-López M,Barrajón-Catalán E,Galiano V,Micol V,Encinar JA

更新日期：2018-10-15 00:00:00

abstract：:Lung cancer is a leading cause of tumor-associated mortality. Fascaplysin, a bis-indole of a marine sponge, exhibit broad anticancer activity as specific CDK4 inhibitor among several other mechanisms, and is investigated as a drug to overcome chemoresistance after the failure of targeted agents or immunotherapy. The c...

journal_title：Marine drugs

authors： Rath B,Hochmair M,Plangger A,Hamilton G

更新日期：2018-10-14 00:00:00

abstract：:To sustainably produce marine fish with a high lipid quality rich in omega-3 fatty acids, alternative sources of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are being identified. Moreover, the use of bioactive compounds that would stimulate the in vivo fatty acid synthesis, such as resveratrol (RV), wou...

journal_title：Marine drugs

authors： Torno C,Staats S,Michl SC,de Pascual-Teresa S,Izquierdo M,Rimbach G,Schulz C

更新日期：2018-10-10 00:00:00

abstract：:Microalgae represent a source of bio-active compounds such as carotenoids with potent anti-inflammatory and antioxidant properties. We aimed to investigate the effects of fucoxanthin (FX) in both in vitro and in vivo skin models. Firstly, its anti-inflammatory activity was evaluated in LPS-stimulated THP-1 macrophages...

journal_title：Marine drugs

authors： Rodríguez-Luna A,Ávila-Román J,González-Rodríguez ML,Cózar MJ,Rabasco AM,Motilva V,Talero E

更新日期：2018-10-10 00:00:00

abstract：:Haloferax mediterranei produces C50 carotenoids that have strong antioxidant properties. The response surface methodology (RSM) tool helps to accurately analyze the most suitable conditions to maximize C50 carotenoids production by haloarchaea. The effects of temperature (15⁻50 °C), pH (4-10), and salinity (5⁻28% NaCl...

journal_title：Marine drugs

authors： Montero-Lobato Z,Ramos-Merchante A,Fuentes JL,Sayago A,Fernández-Recamales Á,Martínez-Espinosa RM,Vega JM,Vílchez C,Garbayo I

更新日期：2018-10-09 00:00:00

abstract：:Fucosterol from edible brown seaweeds has various biological activities, including anti-inflammatory, anti-adipogenic, antiphotoaging, anti-acetylcholinesterase, and anti-beta-secretase 1 activities. However, little is known about its effects on soluble amyloid beta peptide (sAβ)-induced endoplasmic reticulum (ER) str...

journal_title：Marine drugs

authors： Oh JH,Choi JS,Nam TJ

更新日期：2018-10-05 00:00:00

abstract：:A novel wild-type recombinant cold-active α-d-galactosidase (α-PsGal) from the cold-adapted marine bacterium Pseudoalteromonas sp. KMM 701, and its mutants D451A and C494N, were studied in terms of their structural, physicochemical, and catalytic properties. Homology models of the three-dimensional α-PsGal structure, ...

journal_title：Marine drugs

authors： Bakunina I,Slepchenko L,Anastyuk S,Isakov V,Likhatskaya G,Kim N,Tekutyeva L,Son O,Balabanova L

更新日期：2018-09-24 00:00:00

abstract：:The biosynthetic gene cluster for bisucaberin B (1, bsb gene cluster), an N-hydroxy-N-succinyl diamine (HSD)-based siderophore, was cloned from the marine bacterium Tenacibaculum mesophilum, originated from a marine sponge. The bsb gene cluster consists of six open reading frames (ORFs), in contrast to the four ORFs t...

journal_title：Marine drugs

authors： Fujita MJ,Goto Y,Sakai R

更新日期：2018-09-19 00:00:00

abstract：:Two new diphenyl ethers (1 and 2) and four new phenolic bisabolane sesquiterpenoids (3⁻6), together with five known related derivatives, were isolated from the culture of the endophytic fungus Aspergillus flavus QQSG-3 obtained from a fresh branch of Kandelia obobata, which was collected from Huizhou city in the provi...

journal_title：Marine drugs

authors： Wu Y,Chen Y,Huang X,Pan Y,Liu Z,Yan T,Cao W,She Z

更新日期：2018-09-01 00:00:00

abstract：:A marine natural product, pulmonarin B (1), and a series of related tacrine hybrid analogues were synthesized and evaluated as cholinesterase (ChE) inhibitors. The in vitro ChE assay results revealed that 1 showed moderate dual acetylcholinesterase (AChE)/ butyrylcholinesterase (BChE) inhibitory activity, while the hy...

journal_title：Marine drugs

authors： Cheng ZQ,Song JL,Zhu K,Zhang J,Jiang CS,Zhang H

更新日期：2018-08-21 00:00:00

abstract：:To investigate a high cholesterol diet in Alzheimer's disease (AD) mice, they were fed with (2% cholesterol) in five groups with a control group, AD mice group, AD mice plus Meretrix lusoria group, AD mice plus Geloina eros group, and, AD mice plus Corbicula fluminea group for three months, and treated with the fatty ...

journal_title：Marine drugs

authors： Hsieh YL,Teng HJ,Yeh YH,Hsieh CH,Huang CY

更新日期：2018-08-01 00:00:00

abstract：:In our continuous chemical investigation on the marine-derived fungus Dichotomomyces cejpii F31-1, two new polyketides dichocetides B-C (1, 2), two new alkaloids dichotomocejs E-F (3, 4), and three known fumiquinozalines: scequinadoline A (5), quinadoline A (6), and scequinadoline E (7) were discovered from the cultur...

journal_title：Marine drugs

authors： Wu DL,Li HJ,Smith DR,Jaratsittisin J,Xia-Ke-Er XF,Ma WZ,Guo YW,Dong J,Shen J,Yang DP,Lan WJ

更新日期：2018-07-06 00:00:00

abstract：:Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and...

journal_title：Marine drugs

authors： Hasan M,Latifi S,Kahn CJF,Tamayol A,Habibey R,Passeri E,Linder M,Arab-Tehrany E

更新日期：2018-06-25 00:00:00

abstract：:α-Conotoxin TxID was discovered from Conus textile by gene cloning, which has 4/6 inter-cysteine loop spacing and selectively inhibits α3β4 nicotinic acetylcholine receptor (nAChR) subtype. However, TxID is susceptible to modification due to it containing a methionine (Met) residue that easily forms m...

journal_title：Marine drugs

authors： Ren J,Li R,Ning J,Zhu X,Zhangsun D,Wu Y,Luo S

更新日期：2018-06-20 00:00:00

abstract：:Six new polyoxygenated cembrane-based diterpenoids, stellatumolides A⁻C (1⁻3), stellatumonins A and B (4 and 5), and stellatumonone (6), were isolated together with ten known related compounds (7⁻16) from the ethyl acetate (EtOAc) extract of soft coral Sarcophyton stellatum. The structures of the new compounds were es...

journal_title：Marine drugs

authors： Ahmed AF,Chen YW,Huang CY,Tseng YJ,Lin CC,Dai CF,Wu YC,Sheu JH

更新日期：2018-06-14 00:00:00

abstract：:Over the past decades, a number of novel compounds, which are produced in the marine environment, have been found to exhibit the anticancer effects. This review focuses on molecular targets of marine-derived anticancer candidates in clinical and preclinical studies. They are kinases, transcription factors, histone dea...

journal_title：Marine drugs

authors： Song X,Xiong Y,Qi X,Tang W,Dai J,Gu Q,Li J

更新日期：2018-05-22 00:00:00

abstract：:Ascidians (tunicates) are invertebrate chordates, and prolific producers of a wide variety of biologically active secondary metabolites from cyclic peptides to aromatic alkaloids. Several of these compounds have properties which make them candidates for potential new drugs to treat diseases such as cancer. Many of the...

journal_title：Marine drugs

authors： Watters DJ

更新日期：2018-05-13 00:00:00

abstract：:Isolation of marine compounds from living invertebrates represents a major challenge for sustainable and environmentally friendly exploitation of marine bio-resources. To develop innovative technology to trap invertebrate compounds in the open sea, the proof of concept of a system combining external continuous circula...

journal_title：Marine drugs

authors： Vlachou P,Le Goff G,Alonso C,Álvarez PA,Gallard JF,Fokialakis N,Ouazzani J

更新日期：2018-05-06 00:00:00

abstract：:A new sesquiterpenoid 9,10-diolhinokiic acid (1) and a new diterpenoid roussoellol C (2), together with 4 known compounds, were isolated from the extracts of laboratory cultures of marine-derived fungus Talaromyces purpurogenus. 9,10-diolhinokiic acid is the first thujopsene-type sesquiterpenoid containing a 9,10-diol...

journal_title：Marine drugs

authors： Wang W,Wan X,Liu J,Wang J,Zhu H,Chen C,Zhang Y

更新日期：2018-05-02 00:00:00

abstract：:Proteins from different fish species and different raw materials such as fish fillets and by-products have shown promising cardioprotective effects in rodents and humans, including effects on cholesterol metabolism. Blue whiting is used mainly to produce fish meal for the feed industry and during this production, a wa...

journal_title：Marine drugs

authors： Drotningsvik A,Vikøren LA,Mjøs SA,Oterhals Å,Pampanin D,Flesland O,Gudbrandsen OA

更新日期：2018-05-01 00:00:00

abstract：:Although oncolytic viruses provide attractive vehicles for cancer treatment, their adverse effects are largely ignored. In this work, rat C6 glioblastoma cells were subcutaneously xenografted into mice, and a thymidine kinase-deficient oncolytic vaccinia virus (oncoVV) induced severe toxicity in this model. However, o...

journal_title：Marine drugs

authors： Li G,Mei S,Cheng J,Wu T,Luo J

更新日期：2018-04-26 00:00:00

abstract：:Seaweed is a rich source of bioactive sulfated polysaccharides. We obtained six sulfated polysaccharide-rich fractions (UF-0.3, UF-0.5, UF-0.6, UF-0.7, UF-1.0, and UF-2.0) from the green seaweed Udotea flabellum (UF) by proteolytic digestion followed by sequential acetone precipitation. Biochemical analysis of these f...

journal_title：Marine drugs

authors： Presa FB,Marques MLM,Viana RLS,Nobre LTDB,Costa LS,Rocha HAO

更新日期：2018-04-20 00:00:00